Red Blood Cell Indices site
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Showing posts with label MCV. Show all posts
Showing posts with label MCV. Show all posts
Monday, May 5, 2008
MCV
The MCV (Mean Corpuscular Volume) reflects the size of red blood cells by expressing the volume occupied by a single red blood cell.
Cells of normal size are called normocytic, smaller cells are microcytic, and larger cells are macrocytic. These size categories are used to classify anemias. Normocytic anemias have normal-sized cells and a normal MCV; microcytic anemias have small cells and a decreased MCV; and macrocytic anemias have large cells and an increased MCV. Under a microscope, stained red blood cells with a high MCV appear larger than cells with a normal or low MCV.
Normocytic anemia (normal MCV) can be caused by kidney and liver disease, bone marrow disorders, or excessive bleeding or hemolysis of the red blood cells.
Increased readings may indicate macrocytic anemia (high MCV) or B6 or Folic Acid deficiency.
Lack of iron in the diet, thalassemia (a type of hereditary anemia), and chronic illness are the most common causes of microcytic anemia (low MCV).
this information comes from the following website: http://www.saanendoah.com/hemo-mcv.html
Cells of normal size are called normocytic, smaller cells are microcytic, and larger cells are macrocytic. These size categories are used to classify anemias. Normocytic anemias have normal-sized cells and a normal MCV; microcytic anemias have small cells and a decreased MCV; and macrocytic anemias have large cells and an increased MCV. Under a microscope, stained red blood cells with a high MCV appear larger than cells with a normal or low MCV.
Normocytic anemia (normal MCV) can be caused by kidney and liver disease, bone marrow disorders, or excessive bleeding or hemolysis of the red blood cells.
Increased readings may indicate macrocytic anemia (high MCV) or B6 or Folic Acid deficiency.
Lack of iron in the diet, thalassemia (a type of hereditary anemia), and chronic illness are the most common causes of microcytic anemia (low MCV).
this information comes from the following website: http://www.saanendoah.com/hemo-mcv.html
Saturday, February 9, 2008
Elevated MCV
From an MCV Article
Elevated MCV
What might an elevated MCV indicate?
MCV stands for 'mean corpuscular volume', one of the values taken as part of a complete blood count. A group of tests performed on a small amount of blood that provides information about the quantity and quality of each type of blood cell. The MCV is an evaluation of the average volume of each red cell. A high MCV (mean corpuscular volume) is common in MDS and in severe aplastic anemia. MCV is almost invariably elevated also in PNH.
A high MCV is a sign of bone marrow stress in these patients. It does not have independent prognostic significance. It does not warrant treatment per se, unless it is actually due to deficiencies in vitamin B12 or folic acid.
Folic acid or vitamin B12 deficiency should be excluded as causes for the elevated MCV; both of these conditions can cause low blood counts. An increased rate of red blood cell distruction (hemolysis)should also be excluded by checking the reticulocyte count(reticulocytes are larger than mature red blood cells). Hemolysis requires specific treatment. If these conditions are excluded, the high MCV can be attributed to the MDS or aplastic anemia.
The oxygen carrying cells in our body. These bring oxygen to our tissues, and are the most numerous of the blood cells. If these conditions are excluded, the high MCV can be attributed to the MDS or aplastic anemia. It is common in both conditions.
Elevated MCV
What might an elevated MCV indicate?
MCV stands for 'mean corpuscular volume', one of the values taken as part of a complete blood count. A group of tests performed on a small amount of blood that provides information about the quantity and quality of each type of blood cell. The MCV is an evaluation of the average volume of each red cell. A high MCV (mean corpuscular volume) is common in MDS and in severe aplastic anemia. MCV is almost invariably elevated also in PNH.
A high MCV is a sign of bone marrow stress in these patients. It does not have independent prognostic significance. It does not warrant treatment per se, unless it is actually due to deficiencies in vitamin B12 or folic acid.
Folic acid or vitamin B12 deficiency should be excluded as causes for the elevated MCV; both of these conditions can cause low blood counts. An increased rate of red blood cell distruction (hemolysis)should also be excluded by checking the reticulocyte count(reticulocytes are larger than mature red blood cells). Hemolysis requires specific treatment. If these conditions are excluded, the high MCV can be attributed to the MDS or aplastic anemia.
The oxygen carrying cells in our body. These bring oxygen to our tissues, and are the most numerous of the blood cells. If these conditions are excluded, the high MCV can be attributed to the MDS or aplastic anemia. It is common in both conditions.
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